Foscarnet package insert pdf

Pentamidine isethionate is a white crystalline powder soluble in water and glycerin, slightly. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. Foscarnet sodium is a white, crystalline powder containing. Foscarnet trisodium phosphonoformate is a pyrophosphate analog. Foscarnet will not cure cmv eye infection, but it may help to control worsening of the symptoms. Cidofovir injection fda prescribing information, side. Effect of renal disease and hemodialysis on foscarnet. Patients who experience progression of retinitis while receiving foscarnet sodium maintenance therapy may be retreated with the induction and maintenance regimens given above or with a combination of foscarnet sodium injection and ganciclovir see package insert for clinical trials section. Proscar may increase the risk of highgrade prostate cancer 5. Individually dispensed doses of foscarnet should be aseptically transferred and diluted with equal parts of 0. Foscavir injection, phosphonoformic acid foscarnet. Ndc 6332340302 400302 fosphenytoin sodium injection, usp 100 mg pe2 ml 50 mg peml pe phenytoin sodium equivalents for im or iv use rx only 2mlsingle use vials sterile. Mar, 2017 what other drugs will affect foscarnet foscavir.

All were cross resistant to ganciclovir, but remained susceptible to foscarnet. Foscarnet intravenous route description and brand names. Foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. Apr 01, 2020 in vitro, cidofovir was less than 6% bound to plasma or serum proteins over the cidofovir concentration range 0. Keep foscarnet sodium in the container that it came in and keep the container tightly closed. Foscavir foscarnet sodium dose, indications, adverse. Furthermore, prescriber preference may result in a dosing. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. Foscarnet trisodium phosphonoformate is a pyrophosphate analog that has been shown to be effective in the initial treatment of cmv infection as well as for infections caused by other herpes family viruses in patients undergoing renal and bone marrow transplantation.

Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Information for the user foscavir 24 mgml solution for infusion foscarnet read all of this leaflet carefully before you start having this medicine because it contains important information for you. Cidofovirresistant isolates selected in vitro following exposure to increasing concentrations of cidofovir were assessed for susceptibility to ganciclovir and foscarnet 4.

Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Phenobarbital sodium injection, usp is a sterile solution for intramuscular or slow intravenous administration as a longacting barbiturate. This medication is an antiviral that works by stopping the growth of viruses. Vials may be held up to 12 months upon removal from refrigeration to room temperature storage conditions 20c to 25c 68f to 77f.

Foscarnet should be administered at a dose of 40 mgkg, over one hour, every 8 hours, in patients with normal renal function see dosing chart below. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscavir foscarnet sodium injection product insert rubber latex has not been used in the manufacture of this device or drug container closure. Apr 28, 2020 foscarnet trisodium hexahydrate 24 mg ml. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for vistide cidofovir. Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. Foscarnet is usually given for hsv after other antiviral medications have been tried without successful. Foscarnet doses are based on renal function according to the adjusted cockroftgault equation. Proscar is not indicated for use in pediatric patients or women 5. Each ml contains phenobarbital sodium either 65 mg or mg, alcohol 0. Twentysix subjects were enrolled in this study and divided into five groups depending on their degree of renal dysfunction. After reconstitution, it should be administered by intramuscular im or intravenous iv routes see dosage and administration.

If you have any further questions, ask your doctor or nurse. Foscavir tm foscarnet sodium injection hospira inc. If you have seizures, dizziness, or feel sleepy while using foscarnet, avoid driving and doing other tasks or actions that call for you to be alert. Look up information on diseases, tests, and procedures. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may. In vivo micronucleus mouse positive rat oral ld 50 238277 mgkg in vitro cell transformation assay positive version. Fosphenytoin injection, usp 100 mg pe2 ml sodium store. Not determined relevant identified uses of the substance or mixture and uses advised against intended use. The length of your treatment depends on how you respond to the medication. Foscarnet was administered as 40 mgkg iv every 8 hours.

This medication is not a cure for cmv or hsv diseases. For management of immediate sightthreatening cmv retinal lesions i. Foscavir foscarnet sodium this product information is intended only for residents of the united states. Package contains 25 vials of ndc 0069600102 ndc 0069600125 both sizes of vials contain tromethamine, usp tris, hydrochloric acid, nf, or sodium hydroxide, nf, and water for injection, usp. What you need to know before you use cidofovir cidofovir must be administered by a healthcare professional. In vitro, cidofovir was less than 6% bound to plasma or serum proteins over the cidofovir concentration range 0. After binding, the drug blocks the cleavage of the pyrophosphate moiety from deoxynucleotide triphosphates, in turn halting dna chain. Pharmaceutical active used as antiviral details of the supplier of the safety data sheet 2. Careful attention to dosing is required given the doserelated toxicities of foscarnet. Foscavir 24 mgml solution for infusion summary of product. J1455 injection, foscarnet sodium, per mg hcpcs code j1455 the healthcare common prodecure coding system hcpcs is a collection of codes that represent procedures, supplies, products and services which may be provided to medicare beneficiaries and to individuals enrolled in private health insurance programs. The current foscarnet dosing nomogram is complex and based on an unconventional estimate of renal function, which may lead to errors in dose selection. Foscarnet side effects, dosage, interactions drugs.

Intravenous iv solutions of pentamidine isethionate have been shown to be incompatible with fluconazole and foscarnet sodium. In fact, a recent study identified that only onethird of foscarnet doses were within 10% of package insert recommendations. May 18, 2019 foscarnet package insert pdf name of the medicinal product. Foscarnet injection comes as a liquid to be intravenously into a vein.

Sandimmune soft gelatin capsules cyclosporine capsules, usp and sandimmune oral solution. This medication is also used to treat herpes infections hsv that do not respond to treatment with acyclovir acyclovirresistant. This medication is used to control cytomegalovirus cmv eye infections cmv retinitis in persons with aids. The time taken for healing depends on the size of the initial lesion and foscarnet therapy should continue until complete re. You will need an ecg before starting foscarnet and during treatment. Find patient medical information for foscavir intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Controlling cmv retinitis can help decrease the risk of blindness from the infection. If you are a patient needing support and further information relating to the specific indication. Pentam 300 pentamidine isethionate for injection, an antiprotozoal agent, is a sterile, nonpyrogenic, lyophilized product. In all 8 patients assigned to receive foscarnet, lesions healed completely within 1024 days, while none of the 6 patients assigned to vidarabine demonstrated a clinical response.

View detailed import data, price, monthly trends, major importing countries, major ports of foscavir. Foscavir injection, phosphonoformic acid foscarnet dosing. Sep 12, 2019 intravenous infusion solutions of pentamidine isethionate at 1 mgml and 2. Foscavir foscarnet sodium injection side effects, images. Each milliliter of foscavir contains 24 mg of foscarnet sodium hexahydrate in water for injection, usp. Hydrochloric acid may have been added to adjust the ph of the solution to. Clinigen are unable to give guidance on individual medical issues. Foscavir injection is a sterile, isotonic aqueous solution for intravenous administration only. Due to sodium content of foscarnet 240 micromoles 5. Aug 19, 2019 for management of immediate sightthreatening cmv retinal lesions i. The standard 24 mgml solution may be used with or without dilution when using a central venous catheter for infusion. Jacobson ma, gambertoglio jg, aweeka ft, et al foscarnet induced hypocalcemia and effects of foscarnet on calcium metabolism. It binds reversibly near the pyrophosphatebinding site of dna polymerase or reverse transcriptase without requiring further modification 1.

Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na 3 co 5 p6 h 2 o and a molecur weight of 300. Careful personal hygiene is recommended after urination to lessen the potential for local irritation. Cross resistance cidofovirresistant isolates selected in vitro following exposure to increasing concentrations of cidofovir were assessed for susceptibility to ganciclovir and foscarnet 4. Sandimmune cyclosporine should be administered with adrenal corticosteroids but not with other immunosuppressive agents. In one study, 14 patients with no response to acyclovir were randomized to receive foscarnet or vidarabine. Each vial contains fosphenytoin sodium 150 mg equivalent to 100 mg phenytoin sodium, tromethamine tris as a buffer, hydrochloric acid or sodium hydroxide to adjust the ph to 8. Women should not handle crushed or broken proscar tablets when they are pregnant or may potentially be pregnant due to potential risk to a male fetus 5. Dailymed pentam 300 pentamidine isethionate injection. Foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids. Recommended foscarnet dose is not associated with improved. Foscarnet is sometimes combined with another antiviral drug, ganciclovir, when the cmv infection does not respond to either drug used alone for treatment. Foscarnet is usually given for hsv after other antiviral medications have. It is usually infused slowly over 1 to 2 hours every 8 or 12 hours.

Nov 09, 2018 foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. When peripheral veins are used, the solution of foscarnet 24 mgml must be diluted. Foscarnet injection is used to treat symptoms of cytomegalovirus cmv infection of the eyes in patients with acquired immune deficiency syndrome aids. This effect is increased when you also use certain other medicines, including. Buy foscavir foscarnet sodium online blink health rx. Gearhart mo, sorg tb foscarnet induced severe hypomagnesemia and other electrolyte disorders. The infusion time should not be shorter than 1 hour. Package contains 25 vials of ndc 0069600102 ndc 0069600125 both sizes of vials contain tromethamine, usp tris, hydrochloric acid, nf, or sodium. Foscarnet package insert pdf name of the medicinal product. You may receive foscarnet injection in a hospital or you may administer the medication at home. Do not use foscarnet sodium if the original seal over the container opening is broken or missing. What foscavir is and what it is used for foscavir contains a medicine called foscar net. Foscarnet is used for the treatment of invasive cmv disease among patients with suspected or documented ganciclovirresistant cmv. To develop specific dosage guidelines, information on the disposition of this compound in patients with varying degrees of renal function and those requiring dialysis is essential.

Humulin n is an intermediateacting human insulin indicated to improve glycemic control in adult and pediatric patientswith diabetes mellitus. Read all of this leaflet carefully before you start. Foscarnet sodium is administered by controlled intravenous infusion, either by using a central venous line or by using a peripheral vein. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. This medicine is also used to treat herpes simplex virus hsv infections of the skin and.